Mercuric Chloride-Induced Vasculitis in the Brown Norway Rat: a p T Cell-Dependent and -Independent Phases
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Mercuric Chloride Induced Cell Death in Spinal Cord of Embryo in Rat
A B S T R A C TIntroduction: Because of more exposure to mercury compounds, the prenatal and postnatal neurotoxic effects of mercury compounds have gained more attention in last decade. The aim of this study was to investigate the effects of mercuric chloride intoxication on spinal cord development during prenatal period. Methods: 36 adult Sprague-dawley rats after observing vaginal mating plaq...
متن کاملAntioxidants inhibit mercuric chloride-induced early vasculitis.
In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a T(h)2-dominated autoimmune syndrome which includes an early phase of mast cell-dependent vasculitis. We have shown in vitro that oxidative stress up-regulates IL-4 in mast cells and predisposes to degranulation. The aim of this study was to determine whether administration of antioxidants inhibits HgCl(2)-induced early vasculit...
متن کاملMercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4.
Mercurials may induce immune manifestations in susceptible individuals. Mercuric chloride (HgCl2) induced autoimmunity in the Brown Norway (BN) strain but an immuno-suppression in the Lewis strain with, however, autoreactive anti-class II T cells present in both strains. In the present study we looked at modifications of cytokine production by PCR and cytofluorometric analyses in normal BN and ...
متن کاملRegulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat
The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help. There are reciprocal interactions between OX22high and OX22low cells, and it ha...
متن کاملRegulatory Role of OX 22 hlg h T Cells in Mercury - induced Autoimmunity in the Brown Norway Rat
The monoclonal antibody OX22 defines a functional split within CD4 + T cells in the rat, with OX22his h cells mainly producing interleukin 2 (IL-2) and interferon 3~ and responsible for delayed-type hypersensitivity responses, and OX22 j~ cells mainly producing IL-4 and -5 and responsible for providing B cell help. There are reciprocal interactions between OX22his h and OX22 I~ cells, and it ha...
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